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Cytoprotective effects of amifostine and melatonin against radiation-induced oral mucositis in rats
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نویسنده
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park d. ,kim d.h. ,kim w.t. ,nam j.h. ,kim d.c. ,lee k.h. ,ki y.k. ,joo j.h. ,jeon h.s.
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منبع
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international journal of radiation research - 2023 - دوره : 21 - شماره : 2 - صفحه:261 -265
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چکیده
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Background: amifostine (ami) protects against radiotherapy (rt)-induced toxicities and melatonin (mel) is a potent free radical scavenger. this study was performed to investigate the protective effects of ami and mel on radiation-induced oral mucositis (rom). materials and methods: thirty female sprague-dawley rats were randomly divided into five groups as follows: the control (cont), rt alone (rt), rt+ami, rt+mel, and rt+ami+mel. rt groups were irradiated with a single dose of 15 gy to the head. ami (200 mg/kg) and mel (100 mg/kg) were administered intraperitoneally 1 hour before radiation exposure. changes in body weights and histology in irradiated tongue tissues were analyzed 10 days after exposure. results: ami and/or mel treatment significantly prevented irradiation-induced body weight loss and promoted epithelial cell proliferation. mean epithelial thickness was markedly higher in the ami+mel group (73.9 ± 9.7 um) than in the rt group (28.8 ± 13.9 um) (p<0.001), and ki67 expression was significantly higher in ami, mel, and ami+mel groups than in the rt group (p < 0.001). terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) revealed that ami+mel treatment significantly inhibited radiation-induced apoptosis in irradiated epithelium (p=0.006). conclusion: ami and mel administrations similarly protected animals from rom and, when co-administered, had additive effects.
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کلیدواژه
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Amifostine ,melatonin ,radiation-induced oral mucositis ,rats
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آدرس
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pusan national university, biomedical research institute, school of medicine, pusan national university hospital, department of radiation oncology, south Korea, pusan national university, biomedical research institute, school of medicine, pusan national university hospital, department of radiation oncology, south Korea, pusan national university, biomedical research institute, school of medicine, pusan national university hospital, department of radiation oncology, south Korea, pusan national university, biomedical research institute, school of medicine, pusan national university hospital, department of radiation oncology, south Korea, pusan national university, biomedical research institute, school of medicine, pusan national university hospital, department of radiation oncology, south Korea, pusan national university, biomedical research institute, school of medicine, pusan national university hospital, department of radiation oncology, south Korea, pusan national university, pusan national university yangsan hospital, school of medicine, department of radiation oncology, south Korea, pusan national university, pusan national university yangsan hospital, school of medicine, department of radiation oncology, south Korea, pusan national university, pusan national university yangsan hospital, school of medicine, department of radiation oncology, south Korea
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Authors
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