Radiotherapy related prognostic factors in brain metastasis patients who have undergone whole brain radiotherapy or with local boost and survived more than 6 months

Background: in this study, prognostic features of radiation were investigated in cancer patients with 1-10 brain metastases (bm) who have not under surgery and survived longer than 6 months. materials and methods: this retrospective study included 136 patients have lung, breast, colon cancer and malign melanoma (mm) with 1-10 bm. all patients and data of bm patients who lived longer than 6 months radiotherapy (rt) related factors affecting their survival rates were examined. patients were given only wbrt (whole brain radiotherapy) in 8-20 fractions with a 160-300 cgy / day fraction, or wbrt with local boost rt with an additional daily 300-350 cgy fraction. results: when the results were evaluated analysis showed that the having ct, breast cancer, a kps of 60% or more, daily fraction dose of rt affected survival significantly in all patients. then subgroub analysis were obtained according to survival rates, number of metastases more than 5 affects life negatively (r=-0.435 and p=0.03) for survival longer than 6 months (sl6m) and survival shorter or equal than 6 months ss6m. the wbrt doses of 3000 cgy with 300 cgy daily fraction size negatively affected life compared to 2500 cgy with 250 cgy (r=-0.280 and p=0.01). conclusion: it was determined that kps > 60 and limiting wbrt doses up to 250 / 2500 cgy daily and total in patients with bm between 1-10 was the important best prognostic factor due to rt for sl6m, which increased patient performance and survival rates.