Efficacy of Hematoporphyrin mediated photo-sonodynamic therapy on mice breast cancer

Background: a combination of photodynamic and sonodynamic therapy (psdt) may be a non-invasive method for cancer treatment, which incorporates a combination of low-intensity ultrasound, laser radiation, and a sensitizer agent. the goal of this research was to evaluate the effect of psdt with hematoporphyrin-encapsulated mesoporous silica nanoparticles (hp-msns) as a sensitizer in the management of mice breast adenocarcinoma. materials and methods: one hundred and fifty-six female mice (tumor grafted) were separated into 26 groups; including sham, laser (650 nm), 4 groups of laser + hp or msn-hp (2.5 and 5 mg/kg), 4 groups of laser + ultrasound (1and 3 mhz; 1, 2 w/cm2), 16 groups of psdt + hp or hp-msn. the tumor growth factors were used to assess the procedure findings. results: the results indicate that psdt with an injection of hp or hp-msn is effective in delaying tumor growth (p<0.05). overall comparison of data showed a non-significant difference between psdt with hp -msn groups. the time of t2 and t5 in the groups of psdt with hp-msn were increased in comparison with sham and that of psdt with hp groups (p<0.05). the tumor growth inhibition ratio increased in all psdt groups. this increase was transient and declined over 30 days of treatment. psdt + hp-msn had grade i, while other groups had grade iii malignancy in the histological study. conclusion: the research gave profound findings involving the employ of psdt with hp-msn as a photo/ sonosensitizer for treating breast adenocarcinoma implanted in mice.