The dosimetric and clinical comparison between helical tomotherapy and fixed-field intensity-modulated radiotherapy in radical irradiation for cervical cancer

Background: to compare the dosimetric parameters, clinical complications, and efficacy of helical tomotherapy (ht) and fixed-field intensity-modulated radiotherapy (f-imrt) in radical radiotherapy for cervical cancer. materials and method: from november 2016 to december 2018, 77 cervical cancer patients in radical irradiation were selected, 38 patients undergoing treatment with ht and 39 with f-imrt. the dosimetic parameters, clinical complications, and efficacy were compared. results: the homogeneity index (hi) and conformity index (ci) of ht plans were both superior to those of f-imrt plans(p=0.000). ht plans resulted in a reduction in the dosimetric parameters of organs at risk (oars) (p<0.05) except the v10 of small intestine (p=0.682). the incidence of myelosuppression showed no significant differences (p=0.265).the patients with ht had no radiocystitis, grade 2 or above radiation proctitis. the complete remission (cr) rates, efficacy rates (cr+pr) and local control rates of two years were 81.58%,100% and 97.37%. conclusion: ht showed advantages in dosimetry, and provided more superior clinical results. it has a good application prospect in radical irradiation for cervical cancer.