Observation of the effectiveness and safety of the combination of chemotherapy and radiotherapy after the radical resection of progressive gastric cancer

Background: to analyze the effectiveness and safety of combination of 3-dimensional conformal radiotherapy (3d-crt) and s-lox chemotherapy after the radical resection of localized progressive gastric cancer, so as to provide the reference for clinical treatment. materials and methods: we enrolled 82 localized progressive gastric cancer patients undergoing the radical resection of gastric cancer, and divided them using the random digit table into two groups: 39 in the chemotherapy group received the s-lox chemotherapy after operation, and 43 in the combination group received the 3d-crt in combination with s-lox chemotherapy. after treatment, we evaluated the clinical efficacy, adverse reaction, survival rate and recurrence rate of patients in two groups. results: after 6 cycles of treatment, we found no statistical significance in difference of the objective remission rate of patients in two groups (p > 0.05), while the patients in the combination group excelled in the clinical control rate (p < 0.05). in the combination group, 2-year survival rate and survival time of patients were all higher and longer than those in the chemotherapy group (all p < 0.05), with a lower recurrence rate (p < 0.05). furthermore, comparison of the incidence of adverse reactions of patients between two groups showed no significant difference (p > 0.05). conclusion: after the radical resection of the localized progressive gastric cancer, 3d-crt in combination with s-lox chemotherapy improves the clinical control and survival of patients, while reduces the postoperative recurrence, but with no aggravation in side- or toxic-effect, thus worthy of being promoted in clinical practice.