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Intraoperative radiotherapy (IORT) induced keymolecular pathways in tumor bed of breast cancerpatients: a pilot study
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نویسنده
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shahani m. ,shakeri j. ,akbari m. esmaeil ,taft2 a. ,zali h. ,nafisi n. ,rezaei-tavirani m. ,jamaldini ezabady s.h. ,akbari a. ,samsami m.
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منبع
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international journal of radiation research - 2020 - دوره : 18 - شماره : 4 - صفحه:777 -784
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چکیده
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Background: radiotherapy (rt) is recommended to all patients undergoingbreast conserving surgery (bcs). two strategies can be applied to irradiation,external beam rt (ebrt) in addition, intraoperative radiation therapy (iort).the aim of this study was to introduce a protein biomarker panel related tomolecular function of iort. materials and methods: six breast cancer (bc)patients as a pilot study were treated by 12 gy (boost dose) and 21 gy(radical dose). samples tissue included margin before iort (mb), and margin24 hours after iort (ma24 h). high-throughput technology such as isobarictag for relative and absolute quantitation (itraq) was performed to studyproteomic of iort-treated tumor bed. results: we classified 110 differentiallyexpressed proteins (deps) as a protein biomarker panel by mapping theannotated coding region sequences to the reference canonical pathways inthe kegg database. conclusion: the analyses of protein function andsignaling pathways of these deps reveal a molecular response to theeffectiveness of iort.
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کلیدواژه
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Intraoperative radiation therapy (IORT) ,proteomic
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آدرس
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shahid beheshti university of medical sciences, cancer research center, Iran, shahid beheshti university of medical sciences, cancer research center, Iran, shahid beheshti university of medical sciences, cancer research center, Iran, arak university of medical science, faculty of medicine, department of medical biotechnology, Iran, shahid beheshti university of medical sciences, school of advanced technology in medicine, Iran, iran university of medical sciences, breast department, Iran, shahid beheshti university of medical sciences, proteomics research center, faculty of paramedical sciences, Iran, islamic azad university, tehran medical sciences branch, department of genetics, Iran, shahid beheshti university of medical sciences, cancer research center,, Iran, shahid beheshti university of medical sciences, cancer research center, Iran
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Authors
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