Single dose gamma irradiation induced angiogenesisin rat skin hair follicles

Hair follicle cycling usually associated with prominent changes inskin vascularization; through follicular dermal papilla production ofangiogenic factors. the early response of hair follicles to ionizing irradiation(ir) is induction of early anagen hair and appearance of new hair formation.material and method: fifty rats were equally divided into 2 groups; controland γ-rays (10gy) as a single dose, skin biopsy was taken from dorsum of therat 72 hours after irradiation. skin biopsy was examined histopathological andwith immunohistochemical staining cd31. blood samples were collected forbiochemical analysis of tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), interleukin-6 (il-6), malondialdehyde (mda), catalase (cat) andsuperoxide dismutase (sod) results: γ-rays produced epidermal thinning anddermal inflammatory cells together with dermal endothelial proliferation andnew vessels formation around the hair follicle compared with control groupas demonstrated by cd31 staining. furthermore, there was a significantelevation of tnf-α, il-1β and il-6 levels compared to control group.moreover, mda levels increased significantly in γ-rays group and decreasedsignificantly in control group, whereas cat and sod activities decreased inthe γ-rays compared with the control group. conclusion: the early effects of γ-rays on the skin could be beneficial and stimulatory to hair growth