Study of plasma homocysteine, folic acid and vitaminB12 levels for radiation exposed transplanted solidEhirlich tumors

Background: alterations of systemic metabolic parameters are alwayspresent vitamins in cancer in addition radiotherapy may increases andcomplicates these disorders. the analysis of each biochemical metabolicalterations may give more understanding to biochemistry of malignancy andimproving the degree of radiotherapy. the current study aimed to follow upthe changes of folate, vitamin b12 and homocysteine in normal and malignantmice with and without radiation exposure, as floate and b12 metabolism playa role in hypermethylation of certain genes including tumor suppressor andapoptotic genes of cancer. materials and methods: the study was conductedthrough six groups of mice, normal, malignant, normal and malignantexposed gamma radiation with different fractionated doses (0.7 and 1.2 gy).results: comparisons between the results of all groups revealed that: folateand vitamin b12 were lower and homocysteine was higher in gammairradiated malignant and gamma irradiated nonmalignant mice in comparisonwith normal control and malignant mice. folate and vitamin b12 levels werealso lower whereas homocysteine was higher in malignant mice incomparison with normal control group. conclusion: these results denotedthat increased homocysteine or/and decreased folate and vitamin b12 in thetwo malignant exposed groups may have a role in the primary tumorregression leading to the recommendation that preventing up taking of folateand vitamin b12 either as supplements of land nutrients rich with subsequentincrease in homocystein may be beneficial through its toxic effect in stoppingor minimizing tumor progression. the disturbance of vitamins may be due tothe metabolic alterations associated with tumor development.