Possible protective effect of naringin (a citrusbioflavonoid) against kidney injury induced byγ-irradiation and /or iron overload in male rats

Background: the supplementation of natural antioxidants such plantflavonoids may counteract the deleterious actions of gamma-irradiation andiron overload. material and methods: the protective effect of naringin (nin)against kidney injury induced by γ-irradiation (irr) (6.5 gy) and/or irondextran (id) (50 mg/kg. b. w) has been studied in rats given 80 mg/kg b.w ofnin for 14 days before, and for 7 days after the exposure to γ-irradiation and/or iron dextran. results: a significant elevation in serum urea, creatinine,glucose concentrations, and an increase in kidney lipid peroxidation (lpo),ros and metallothionein (mts) were observed in rats treated with γ-radiationand/or id. in addition, a significant decrease in kidney gsh, sod content,serum total protein, albumin and a/g ratio were also recorded. tissue organdisplayed some changes in trace element concentrations, which may be dueto the radiation and/or id ability to induce oxidative stress. treatment withnin revealed a significant modulation in the biochemical tested parametersand a profound improvement in the activity of antioxidant status; therebyappeared to be effective in minimizing the γ-irradiation and/or id-inducedincrease in lpo and ros as well as changes in essential trace elements inkidney tissue organs. the positive and negative correlation between traceelements and antioxidant markers illuminated antioxidant properties inaddition to being an integral part of antioxidant enzymes. conclusion: nin hasa role in protecting against oxidative stress and kidney injury produced byiron dextran and/or γ- irradiation