The relationship between collective effective doses of radiation and urinary concentration of 8-Dihydroxy- 2'-Deoxyguanosine among radiography staff

Background: the effect of ionizing radiation of 8-hydroxy- 2’-deoxyguanosine (8-ohdg) level in radiographers’ urine as the oxidativedamage biomarker was investigated in this study and this biomarker wascompared with the collective effective doses. materials and methods: thesamples were selected into two categories in this cross-sectional study, 35 ofwhom were from different radiography groups (including nuclear medicine,radiology, radiotherapy, ct scan), and 35 subjects were from the staff whohad no exposure to radiation. the results of the film badge were gatheredfrom the hospitals, and the collective effective dose was obtained accordingto the respective formula. then, at the end of the work shift, the urinesamples were taken to determine the 8-ohdg concentration. the sampleswere obtained via the spe (solid-phase extraction) method. after that, the 8-ohdg concentration was read by the gc/ms analyzer. finally, the dataresulted from the 8-ohdg concentration and the collective effective dose ofthe radiation were analyzed by the spss software. result: the results showedthat the 8-hydroxy-2-deoxy-guanosine concentration in the urine of theradiation workers had significant correlation with the collective effective doseof the radiation the past 6 periods (p=0.009) and also with the collectiveeffective dose of the radiation of the 30 last periods (p=0.009). conclusion:observing the radiation protection principles by radiation workers results indecreased radiation and, in turn, reduces the level of oxidative stress, thus,reducing the potential effects of radiation.