Thermal enhancement effect on chemo-radiation of glioblastoma multiform

Hyperthermia plays a significant role in the chemo-radiotherapyeffect in different malignancies. in this research, we treated glioblastomamultiform (gbm) patients with hyperthermia (ht) along with thechemoradiation, in order to evaluate ht efficacy in terms of tumor volumechanges, survival time, and probability. materials and methods:thirty-eight gbm patients were distributed into two groups identified aschemoradiation (crt), and also crt plus ht (crht). the karnofskyperformance status scale (kps) was done before, immediately and threemonths after treatments. capacitive hyperthermia device was used atfrequency of 13.56 mhz (celsius 42+ gmbh, germany) for ht one hour beforethe radiotherapy for 10-12 sessions. patients in both groups underwent mrimaging (1.5 tesla) before, 3 and 6 months after the treatments. thermalenhancement factors (tef) were attained in terms of clinical target volumechanges, tef(ctv), and survival probability (sp) or tef(sp). results: ageranges were from 27-73 years (mean=50) and 27-65 years (mean=50) for crtand crht groups, respectively. for 53% and 47% of cases biopsy and partialresection were accomplished in both groups, respectively. means andstandard deviations of tumor volumes were 135.42±92.5 and 58.4±104.1cm3before treatment in crt and crht groups, respectively, with no significantdifference (p= 0.2). tef(ctv) value was attained to be as 1.54 and 1.70 forthree and six months after treatments, respectively, tef(sp) was also equal tothe 1.90. conclusion: ht enhanced the chemoradiation effects throughoutthe patient survival probability and kps. tef may reflect the hyperthermiaefficacy for a given radiation dose.