Safe chemotherapy and targeted therapy for treating locally advanced NPC in a G6PD-deficient patient: case report and literature review

The article was first report a case of a 32-year-old female with npc that is g6pd-deficient. the patient completed induction chemotherapy and concomitant chemoradiotherapy successfully. the patient experienced grade 1 neutropenia , grade 1 diarrhea, and grade 2 acne-like skin reactions during the three cycles of induction chemotherapy. grade 1 neutropenia, grade 1 diarrhea, grade 2 oral mucositis and grade 1 skin reactions were observed during the concomitant chemoradiotherapy. no hemolytic events were observed. we conclude that it is safe for g6pd-deficient patients with npc to received chemotherapy and targeted therapy.