Lateral ventricule invasion and radiation dose to subventricular zone: Their impact to the treatment outcomes of glioblastoma

Background: this study was conducted to evaluate the recurrence patterns ofgbm in regard to its contact with lvs, the relation between radiation doses tosubventrivular zone (svz). materials and methods: between 2012 and 2014, 80adult patients with gbm were included this trial. median follow-up period was 15months. median tumor size was 4.5 cm (1.3-8 cm), where 58% of the patients had atumor larger than 4 cm. all of the lesions were located supratentorial part of brain.tumors were classified based on whether the mass involved the svz and/or lvs.reccurrence patterns and treatment outcomes were compared. results: tumorprogression occurred in 60 (75%) of the patients. of those 31 (51.6%) werein-field. median progression-free survival (pfs) and median overall survival(os) times were 11 and 15 months, respectively. on multivariate analysis, thenegative prognostic factors were maximal surgical resection (p=0.027),lv-invading tumor (p=0.001) and p53 positivity (p=0.034) for pfs. it wasfound that the patients receiving >50 gy to isvz dose (p=0.024) or >40 gy tocsvz dose (p=0.002) or >40 gy to bsvz dose (p=0.028) or >50 gy to bsvz dose(p=0.008) tended to have more recurrences. both in-field and out-fieldrecurrences were not affected by higher radiation doses. conclusion: lvsinvading and/or location close to the svzs can be considered as an importantprognostic factor in terms of decreased pfs and os rates. additionally both svzssparing and dose escalation to svzs approaches are required to be evaluated infurther researches.