in vivo assessment of gamma rays, electronbeam irradiation plus a commercial toxin binder (milbond-tx) as an antiaflatoxin b1 in a chicken model

Background: aspergillus flavus is the most important fungus for production of aflatoxin b1 (afb1). this study evaluated the ability of gamma rays (grs) and electron-beam irradiation (ebi) to counteract the deleterious effects of aflatoxin b1 (afb1) in a chicken model.methods: overall, 168 one-day-old male coturnix quails were assigned to eight treatments for 42 d in tehran, iran, in 2010 and 2011. two dietary inclusion rates of afb1 (0 and 2 ppm) and toxin binders, such as 0, 27 kgy doses of grs, 27 kgy doses of ebi, and 0.3% of commercial toxin binder-milbond-tx, were tested in a 2×4 factorial manner. serum biochemical parameters, immune response, and dietary treatments on factors associated with kidney and lipid profiles were determined on day 42.results: afb1 significantly decreased the hematological parameters (hematocrit in 21 and 42 d), immune response (white blood cell (wbc), heterophil to lymphocyte ratio (h/l) and sheep red blood cell (srbc)), and blood chemical factors (glucose, albumin, total protein, and triglycerides) compared to the control diet (p<0.05). it also significantly increased the calcium, phosphorus, uric acid, and low-density lipoprotein (ldl) levels (p<0.05). the addition of toxin binders, such as grs, ebi, and milbond-tx, in the contaminated diets significantly diminished the inhibitory effects of dietary afb1 (p<0.05) on the hematological parameters, immune response, blood chemical factors, and factors associated with kidney and lipids profile with no differences compared to the control diet.conclusion: the addition of these toxin binders may reduce the adverse effects produced by the presence of afb1 in japanese quails’ diets.