Helianthus Annuus Leaf Ameliorates Postprandial Hyperglycaemia By Inhibiting Carbohydrate Hydrolyzing Enzymes Associated With Type-2 Diabetes

Background: diabetes mellitus is a chronic disease. decreasing postprandial hyperglycemiaby retarding glucose absorption through inhibiting carbohydrates digesting enzymes (α-amylaseand α-glucosidase) is one of many approaches used for the management of this disease. thisstudy was aimed at evaluating the normoglycaemic potential of helianthus annuus leaf.methods: the effect of the in vitro inhibitory of different extracts (acetone, ethyl acetate andhexane) of the plant was assessed on the activities of diabetes-related enzymes (α-amylaseand α-glucosidase).results: the hexane extract of h. annuus leaf displayed the best inhibitory activity against α-amylase and α-glucosidase as indicated by the ic50 values (3.92 ± 0.02 mg ml^-1) and (3.29 ±0.12 mg ml^-1), respectively. lineweaver-burk plot of inhibition of α-amylase and α-glucosidaseby this extract showed that it was competitive and non-competitive mode, respectively.conclusion: h. annuus leaf possesses hypoglycaemic potential which may be due to theinhibition of pancreatic α-amylase and intestinal α-glucosidase.