Biochemical Alteration Induced By Cadmium and Lead in Common Carp Via An Experimental Food Chain

Background: evaluation on the toxicity of two mainly contaminant heavy metals, cadmium(cd) and lead (pb) through the food chain was the aim of this study.methods: a total number of 270 healthy common carp (4±1.14 g) in april, 2015 transported tothe khatam alanbia university of technology, behbahan, iran. fishes were divided into threegroups and transferred to the 20 l aquaria each containing 30 juveniles. the first group(control) fed by metal-free artemia fransiscan anauplii throughout the experiment. the secondand third groups were feeding by cd and pb (1.5 mg/l free ion) contaminated nauplia,respectively. the experimental study was carried out for three weeks and sampling was done in4th, 7th, 14th and 21st days. finally, the alterations in plasma biochemical responses weredetermined.results: alanine aminotransferase and aspartate aminotransferase activities increased inresponse to feeding pb-contaminated nauplia. creatine phosphokinase activity showedsignificant increase in fourth day about both cd and pb and at the end of experiment only in cdtreatment (p<0.05). cholesterol and triglyceride were increased significantly only for pb(p<0.05). plasma glucose and creatinine levels increased by both heavy metals compared tothe control but glucose just remained high only for pb at the end of the experiment. totalprotein, albumin and globulin were significantly declined in both metal contaminated groups(p<0.05).conclusion: it seems pb had a greater toxicity than cd through the food chain and it may bedue to its more trophic transfer than cd.