rhabdomyolysis and high-sensitivity troponin i activity in acutely intoxicated patients

Background: this study evaluated the high-sensitivity troponin i (hs-tni) activity in patients with rhabdomyolysis following acute intoxication with either psychotropic drugs or other chemical agents.methods: this study randomly recruited 140 patients suffering from rhabdomyolysis. they were divided into two groups affected by either psychotropic drugs or chemical agents. hs-tni was measured in all patients with rhabdomyolysis three times (i.e., the first, third, and fifth days of hospitalization).results: the mean hs-tni values on the first, third, and fifth days were obtained at 27.7±78.3 µg/l, 43.7±135.9 µg/l, and 28.73±57.01g/l, respectively. on the third day of hospitalization, hs-tni was significantly higher in all patients, compared to the fifth day. according to the intoxication agent on the first day, the highest values of hs-tni were determined in methadone intoxications (n = 5) - 279.7 ± 190.7 µg / l, benzodiazepines (n = 3) - 213.9 ± 232.5 µg / l, other drugs (n = 1) - 138.4 µg / l. analysis by the type of intoxication on the first, third, and fifth days showed that hs-tni values were insignificantly higher in the psychotropic group, compared to the chemical group.conclusion: clinicians should be aware of the possibility of increasing hs-tni in patients with rhabdomyolysis due to acute intoxication. elevated levels of hs-tni in psychotropic intoxications were likely related to the specific etiologies, such as illicit substance use, while chemical intoxication was associated with the clinical outcome of intoxication.