alium cepa peel extract plays a protective role in ethanol-induced kidney and liver toxiicity in balb/c mice: a histological study.

Background: allium cepa peels are byproducts obtained from the onion bulb, which has abundant bioactive components that have been used in the treatment of various ailments across the globe. the current study investigates the effect of allium cepa on the histology of the kidney and liver tissue following alcohol toxicity.methods: a total of 24 balb/c mice, three months old and weighing 15-22 g, were grouped into four groups of 6 mice each. they were administered treatment as follows: group i was considered the positive control and received an equal volume of distilled water; group ii (negative control) was administered 20% ethanol at 10 mg/kg; group iii was administered 50 g/kg of allium cepa peel extract and 20% ethanol at 10 ml/kg; and group iv received 100 g/kg of allium cepa peel extract and 20% ethanol at 10 ml/kg. the treatment continued for 28 days, after which the mice were sacrificed, and the liver and kidney tissues were dissected for routine histological preparation.results: administration of allium cepa extract caused a non-significant increase in the body weight in treated groups, significantly (p<0.05) increased the weight of the kidneys, significantly (p<0.05) decreased in the weight of the liver, preserved the hepatocytes in the liver and the renal epithelium and glomerulus of the kidney tissue.conclusion: allium cepa, in the present investigation, shows potential as a candidate to protect against ethanol-induced hepatotoxicity through its effects on renal and hepatic tissue. however, further studies are required to determine the exact mechanisms involved and the active biocomponents.