Lactobacillus Paracasei Has Anti-Inflammatory Effect on the Heart Failure Induced By Isoproterenol in Rats

Background: heart failure (hf) has become one of the most prevalent cardiovascular problems worldwide. considering the beneficial effects of probiotics on human health, we aimed to investigate the anti-inflammatory effect of oral administration of lactobacillus paracasei in hf induced by isoproterenol. methods: forty wistar male rats weighing 80g on average were randomly assigned to five groups of eight each: control, probiotic, hf model, prophylaxis including probiotic + hf, and treatment (hf+probiotic). the rats were treated and examined over 30 days. heart failure was induced by the subcutaneous injection of isoproterenol (5 mg/kg) once daily for 10 days. at the completion of the study, the ratios of body, heart, and left ventricle weights (bw, hw & lvw), serum tnf-α levels, measured by elisa, myocardial histopathological lesions were determined and compared among the groups. cardiac hypertrophy was defined by comparing the lvw to total body weight for each animal. results: the lvw and lvw/hw ratio were significantly increased in the rats with hf (p<0.05). in the treatment group, the lvw/hw and serum tnf-α level were lower compared to those in the hf group. also, the infiltration of inflammatory cells, necrosis, and myocardial hypertrophy were remarkably lower than those in the hf group. conclusion: the study findings indicate that the oral administration of lactobacillus paracasei subsp. paracasei-8700: 2 can reduce the cardiac hypertrophy, failure and inflammation induced by the administration of isoproterenol in rats. therefore, the study results suggest a novel approach for the management and potential prevention of heart failure.