Histopathological Study of Protective Effects of Honey on Subacute Toxicity of Acrylamide-Induced Tissue Lesions in Rats’ Brain and Liver

Background: the therapeutic potential of honey is related to antioxidant activity against reactive oxygen species because it contains compounds such as polyphenols; therefore, we evaluated the potential protective effect of honey on subacute toxicity of acr by histopathologic study on tissue lesions in rat. methods: in ferdowsi university of mashhad, mashhad, iran, 2016, male wistar rats were divided into 7 groups. to induce toxicity, acr was injected (50 mg/kg for 11 d) to rats in 5 groups. in treatment groups, rats received three doses of honey 1.25, 2.5, and 5 g/kg in addition to the acr. the two remaining groups received vitamin e (200 iu/kg) and normal saline as positive and negative control respectively. on the last day, after necropsy, tissue specimens from brain and liver were collected for histopathological studies. results: receiving of acr caused tissue injuries including degeneration, necrosis, hyperemia, hemorrhage and inflammation in liver; ischemic cell change, hyperemia, hemorrhage and edema in brain tissue. administration of honey considerably reduced tissue damages caused by acr, particularly with dosage 5 g/kg. conclusion: the severity of tissue lesions caused by the acr can be reduced by honey, likely through its antioxidant activity. increasing concentrations of honey will enhance its effectiveness.