the relationship between serum vitamin d level and premenstrual syndrome in iranian women

Background: premenstrual syndrome (pms) is among the most unfavorable problems in women in reproductive age; however its pathophysiology is still not fully confirmed. vitamin d as an immunomodulator could prevent inflammatory state before and during menstruation. objective: the aim was to investigate whether there is any relationship between serum vitamin d levels and pms. materials and methods: in total, 82 women participate in this case-control study which was conducted in shahid akbar-abadi hospital from november 2013 to march 2015. categorization was based on an iranian version of the premenstrual symptoms screening tool (psst). levels of 25 hydroxy-vitamin d3 (25ohd) were determined by using 25-oh vitamin d elisa kit in luteal phase. characteristics of participants and vitamin d levels were compared between two groups by using independent sample t-test. results: menarche age of women with pms was significantly lower than normal women (p=0.04). body mass index was not statistically different between groups. we observed a high rate of vitamin d deficiency and also its severe deficiency in both pms and non-pms groups. however, our study demonstrated no significant difference in the levels of serum 25ohd between the two groups. conclusion: it seems there is no association between pms and serum levels of vitamin d3; however, the high rate of vitamin d deficiency among young iranian women emerges special health care considerations in this group.