analysis of ovarian reserve markers (amh, fsh, afc) in different age strata in ivf/icsi patients

Background: the predictive roles of follicle stimulating hormone (fsh), anti-mullerian hormone (amh) and antral follicle count (afc) as ovarian reserve markers in women with different age groups are not established well. objective: this study compares the value of fsh, amh and afc at the time of in vitro fertilization (ivf) treatment in different age groups. materials and methods: in this cross-sectional study, 103 women aged 20-43 years candidates for ivf/icsi cycle were recruited. fsh, amh and afc on day 3 of menstrual cycle were measured. the relationship of these measured markers with outcome variables (oocytes number, number of frozen/fresh embryo and chemical and clinical pregnancy) was assessed in different age groups (i.e. 20-32, 33-37 and 38-43 years). results: our results show that age was correlated with clinical pregnancy, oocyte count and fresh and frozen embryo (p<0.001). amh, afc and fsh were not correlated with clinical or chemical pregnancy at total population or age subgroups except the significant correlation of afc with clinical pregnancy at 33-37 years old group. afc was correlated with oocyte count and the number of fresh and frozen embryos in the ages group 20-32 years. in this age group, amh was correlated with fresh and frozen embryos. amh, afc and fsh were correlated with oocyte count and the number of fresh embryos in age group 33-37 years. amh was correlated with oocyte count and the number of fresh embryos in 38-43 years old group. conclusion: we concluded that the age is the superior predictor of ivf outcome and amh and afc are variable predicting markers of ovarian reserve in different age groups.