endometrial expression of β3 integrin, calcitonin and plexin-b1 in the window of implantation in women with unexplained infertility

Background: endometrial receptivity plays a key role in the establishment of successful implantation and its impairment may contribute to subfertility and limit the assisted reproduction techniques (art) success. objective: the aim of present study was to investigate endometrial receptivity in terms of β3 integrin, calcitonin and plexin-b1 expression in women with unexplained infertility. materials and methods: we evaluated expression of β3 integrin, calcitonin and plexin-b1 through mrna level measurement with real-time rt-pcr, in the endometrium of 16 infertile women with unexplained infertility and 10 fertile women. endometrial biopsies were collected during a single menstrual cycle on postovulatory day lh+7 in each subject. results: significant differences regarding β3 integrin and calcitonin expression levels found between patients with unexplained infertility and the fertile women. endometrial plexin-b1 expression levels showed no significant difference between fertile and infertile women. there were significant correlations between expression of β3 integrin with calcitonin and plexin-b1 in fertile and infertile women. conclusion: reduced in endometrial expression of β3 integrin and calcitonin alone or together may contribute to unexplained infertility and these genes could account as the potential molecular markers of infertility.