investigating the effects of citrullus colocynthis pulp on oxidative stress in testes and epididymis in streptozotocin-induced diabetic male rats

Background: diabetes mellitus is one of the most common metabolic diseases in humans, affecting 100 million people around the world. objective: investigating the effects of citrullus colocynthis pulp on oxidant and antioxidant factors of testes and epididymis in streptozotocin-induced diabetic male rats. materials and methods: thirty two male rats were divided into four groups (n=8) 1) n (normal) group, 2) n+c group, 3) d (diabetic) group and 4) d+c group. groups n and d received normal saline 2 ml orally for two weeks and groups n+c and d+c received 10 mg/kg.bw citrullus colocynthis pulp orally for two weeks. diabetes was induced by single intraperitoneal injection of streptozotocin (stz) at 65 mg/kg. results: d group had a significant increase in h2o2 (hydrogen peroxide) and mda (malondialdehyde) concentrations, and cat (catalase) activity, and also a significant decrease in peroxidase (pod) activity compared to n group. d+c group had a significant decrease in h2o2 and mda concentrations and, cat activity and significant increase in pod activity compared to d group. conclusion: citrullus colocynthis pulp in two weeks had beneficial effects on oxidants and antioxidants changes in reproductive system in streptozotocin-induced diabetic rats.