successful pregnancy and live birth after intrauterine administration of autologous platelet-rich plasma in a woman with recurrent implantation failure: a case report

Background: platelets contain a significant amount of growth factors that have positive effects on local tissue repair and endometrial receptivity. case: here we present a 45-yr-old woman with primary infertility and two failed in vitro fertilization (ivf) cycles who was candidate to receive donor eggs. five consecutive frozen-thawed embryo transfer cycles with good quality embryos were performed within 2 yr. with the diagnosis of recurrent implantation failure (rif), the patient was treated for improving endometrial receptivity with intrauterine administration of autologous platelet-rich plasma (prp), 24 hr before embryo transfer. the patient gave birth to a healthy baby boy weighing 2350 gr in the cesarean section. conclusion: extensive literature search suggests that this is the first successful pregnancy after administration of prp in a woman with rif. local administration of prp before embryo transfer may play a vital role in successful implantation .