granulocyte colony-stimulating factor gene rs1042658 variant and susceptibility to idiopathic recurrent pregnancy loss: a case-control study

Background: granulocyte colony-in stimulating factor (g-csf) gene can be a potential candidate gene implicated recurrent pregnancy loss (rpl), a common complication of pregnancy with the prevalence of 1-5% among women of reproductive age. objective: to investigate the association between rs1042658 polymorphism in the 3' untranslated region (3'utr) of g-csf gene and the risk of unexplained rpl among iranian women. materials and methods: in total, 122 women with unexplained rpl and 140 healthy postmenopausal women as a control group were enrolled in this case-control study. tetra-primer amplification refractory mutation system-polymerase chain reaction was performed to determine the rs1042658 genotypes in all subjects. results: statistically significant differences were detected between the distribution frequencies of both heterozygote ct, and carriage of t allele (tt+ct) genotypes of the rs1042658 between case and control groups. allelic association was not observed with rpl. conclusion: regarding the results of the present study, g-csf rs1042658 gene polymorphism could be considered as a probable risk factor for unexplained rpl among iranian women.