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Granulocyte Colony-Stimulating Factor Gene Rs1042658 Variant and Susceptibility To Idiopathic Recurrent Pregnancy Loss: A Case-Control Study
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نویسنده
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Nasiri Mahboobeh ,Jahangirizadeh Kobra
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منبع
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International Journal Of Reproductive Biomedicine - 2018 - دوره : 16 - شماره : 1 - صفحه:35 -40
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چکیده
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Background: granulocyte colony-in stimulating factor (g-csf) gene can be a potential candidate gene implicated recurrent pregnancy loss (rpl), a common complication of pregnancy with the prevalence of 1-5% among women of reproductive age. objective: to investigate the association between rs1042658 polymorphism in the 3' untranslated region (3'utr) of g-csf gene and the risk of unexplained rpl among iranian women. materials and methods: in total, 122 women with unexplained rpl and 140 healthy postmenopausal women as a control group were enrolled in this case-control study. tetra-primer amplification refractory mutation system-polymerase chain reaction was performed to determine the rs1042658 genotypes in all subjects. results: statistically significant differences were detected between the distribution frequencies of both heterozygote ct, and carriage of t allele (tt+ct) genotypes of the rs1042658 between case and control groups. allelic association was not observed with rpl. conclusion: regarding the results of the present study, g-csf rs1042658 gene polymorphism could be considered as a probable risk factor for unexplained rpl among iranian women.
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کلیدواژه
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Granulocyte Colony-Stimulating Factor ,Recurrent Pregnancy Loss ,Polymorphism.
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آدرس
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Islamic Azad University, Arsanjan Branch, Department Of Biology, ایران, Islamic Azad University, Arsanjan Branch, Department Of Biology, ایران
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واریانت ناحیه 3َ ترجمه نشونده ژن فاکتور محرک کلونی گرانولوسیتی و استعداد ابتلا به سقط مکرر جنین: یک مطالعه مورد شاهدی
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Authors
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نصیری محبوبه ,جهانگیری زاده کبری
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