the effect of resveratrol on oxidative stress in the liver and serum of a rat model of polycystic ovary syndrome: an experimental study

Background: studies of oxidative status in polycystic ovarian syndrome (pcos) patients are limited with inconsistent results. the effects of resveratrol as a natural antioxidant on oxidative status in pcos aren’t clear. objective: this study evaluated effects of resveratrol on oxidative stress in the liver and serum of the pcos rats. materials and methods: fifteen female wistar rats (3 wk old) were divided into 3 groups (n=5/each e): control group, pco-control group, and pco-resveratrol group. for induction of polycystic ovary phenotype, testosterone enanthate 10 mg/kg was injected for 35 days subcutaneously. then, resveratrol 10 mg/kg was injected intraperitoneally for 28 days to rats of the pco-resveratrol group. ovarian sections were stained with hematoxylin/eosin. the serum glucose and insulin and the levels of malondialdehyde (mda) and total antioxidant capacity (tac) in serum and liver were measured. results: control animals showed normal ovarian morphology and pco-control animals exhibited cystic follicles. there were no significant differences in liver tac between groups. the serum mda (p=0.034), and homeostatic model assessment insulin resistance (homa-ir) (p=0.014) levels in pco-control rats were higher than the controls. the liver mda in pco-control rats was more than that of controls (p=0.001). the homa-ir (p=0.008) and serum mda (p=0.006) levels in pco-control rats were more than those of pco-resveratrol rats (p=0.008). in pco-resveratrol group, serum tac was higher than that of pco-control group (p=0.022) and liver mda was more than controls (p=0.01). conclusion: results indicated that the induction of pcos in rats increased lipid peroxidation and insulin resistance and resveratrol improved these complications.