controlled ovarian stimulation with r-fsh plus r-lh vs. hmg plus r-fsh in patients candidate for ivf/icsi cycles: an rct

Background: different combination of gonadotropin preparation has been introduced with no definite superiority of one over others in in vitro fertilization (ivf), but individualized regimens for each patient are needed. objective: the aim of the present study was to investigate the effect of controlled ovarian stimulation with recombinant- follicle stimulating hormone (r-fsh) plus recombinant-luteinizing hormone (rlh) versus human menopausal gonadotropin (hmg) plus r-fsh on fertility outcomes in ivf patients. materials and methods: this is a randomized clinical trial study that was performed from october 2014-april 2016 on 140 infertile patients with a set of inclusion criteria that referred to infertility clinics in vali- asr and gandhi hospital in tehran. the women were randomly divided into two treatment groups. the first group (n=70) received rfsh from the second day of cycle and was added hmg in 6^th day and the 2^nd group (n=70), received rfsh from the second day of cycle and was added recombinant-lh in 6^th day. then ovum pick-up and embryo transfer were performed. in this study, we assessed the outcomes such as; chemical and clinical pregnancy rate, live birth and abortion rate. results: number of follicles in ovaries, total number of oocytes or m2 oocytes and quality of fetuses has no significant differences between two groups (p>0.05). total number of fetuses were significantly higher in patients who received rfsh + hmg (p=0.02). fertility outcomes consisted of: live birth rate, chemical pregnancy and clinical pregnancy rate were higher in rfsh + hmg group in comparison to rfsh +r-lh group (p<0.05). conclusion: it seems that in ivf patients, hmg + rfsh used for controlled ovarian hyperstimulation have better effects on fertility outcomes, but in order to verify the results, it is recommended to implement studies on more patients.