evaluation of vitamin d status and its correlation with oxidative stress markers in women with polycystic ovary syndrome

Background: there is little evidence about antioxidant properties of vitamin d. recent studies suggest that oxidative stress may play a major role in the pathophysiology of polycystic ovary syndrome (pcos), but the association of vitamin d with oxidative stress is still not known in pcos. objective: the goal of the present study was to evaluate the correlation between serum 25-hydroxy vitamin d and oxidative stress markers in pcos group compared to control group. materials and methods: 60 pcos women (20-40 yr old) and 90 healthy women as control group were participated in this case-control study. fasting serum level of 25-hydroxy vitamin d 25(oh) d, glucose, insulin, calcium, malondialdehyde (mda), protein carbonyl (pc), also homeostasis model assessment for insulin resistance (homa-ir) and fasting glucose to insulin ratio (fgir) were measured. results: it was found that the mean of serum 25(oh)d was lower in the pcos group (10.76±4.17) than in the control group (12.07±6.26) but this difference was not statistically significant (p=0.125). fasting insulin, homa-ir and mda were significantly higher in the pcos patients as compared to the controls, whereas pc level did not differ for the two groups (p=0.156). no significant correlations were found between 25(oh) d levels and oxidative stress markers (mda and pc). conclusion: the findings indicated no significant differences in the serum 25(oh) d levels between the pcos patients and the matched controls. also, no correlation was found between the serum vitamin d levels and oxidative stress markers in both groups.