Antispasmodic effect of Physalis alkekengi fruit extract on rat uterus

Background: studies have shown that physalis alkekengi reduces implantation and induces antifertility in rat. in iranian traditional medicine it is believed that this plant has abortifacient and antifertility activities.objective: the goal of this study was to evaluate the effect of physalis alkekengi ripe fruit hydroalcoholic extract (pfe) on uterine contractility and its possible mechanismis). materials and methods: extraction of physalis alkekengi fruit was carried out by maceration method (70% alcohol). uterus was dissected out from adult non-pregnant rat(wistar) and contracted by kci (60mm) or oxytocin (iomu/ml) in an organ bath containing de jalon solution and the effect of pfe on the uterine contractions was investigated. furthermore, the role of a- and ~-adrenoceptors, opioid receptors, nitric oxide and cyclic guanosine monophosphate synthesis inhibitors on the extract effectswere evaluated. results: kci- and oxytocin-induced uterine contractions were inhibited (p