association study of glutathione s-transferase polymorphisms and risk of endometriosis in an iranian population

Background: endometriosis influenced by both genetic and environmental factors. associations of glutathione s-transferases (gsts) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent.objective: we examined the associations of gstm1 and gstt1 null genotypes and gstp1 313 a/g polymorphisms with endometriosis in an iranian population. materials and methods: in this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. the genotyping was determined using multiplex pcr and pcr- rflp methods.results: the gstm1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). there was no significant difference between the frequency of gstt1 genotypes between the cases and controls. the gstp1 313 ag genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%). conclusion: our results showed that gstm1 and gstp1 polymorphisms may be associated with susceptibility of endometriosis in iranian women.