significant correlation of angiotensin converting enzyme and glycoprotein iiia genes polymorphisms with unexplained recurrent pregnancy loss in north of iran

Background: spontaneous abortion is considered as the most complex problem during pregnancy. thrombophilia is resumed as a cause of recurrent pregnancy loss (rpl). glycoprotein iiia (gpiiia) gene is involved in thrombosis and abortion. angiotensin converting enzyme (ace) converts angiotensin i to angiotensin ii and is involved in thrombosis. the most common polymorphism in this gene is the insertion/deletion (i/d).objective: in this study, we analyzed the association between ace i/d and gpiiia c.98c >t polymorphisms in women with unexplained rpl from the north of iran.materials and methods: sample population consisted of 100 women with unexplained rpl and 100 controls. the ace i/d and gpiiia c.98c>t polymorphisms were genotyped by tetra-arms pcr. the association between genotypes frequency and rpl were analyzed using χp2p and exact fisher tests. associated risk with double genotype combinations was also investigated by binary logistic regression.results: there was significant association between ace dd genotype and rpl (or=2.04; 95% ci=0.94-4.44; p=0.036). ace d allele was also significantly associated with the rpl (or=1.59; 95% ci=1.05-2.41; p=0.013). no significant association was observed between gpiiia c.98c>t polymorphism and rpl.conclusion: ace i/d polymorphism may probably be a prognostic factor in female family members of women with the history of recurrent abortion.