morphological and morphometrical changes of endometrim after application of estrogen and progesterone during luteal phase in the superovulated mice

Background: the application of luteal phase supplementation hormones to increase theimplantation rate is on debate among researchers.objective: in this study, the morphological and morphometrical assessment ofsuperovulated mice endometrium were investigated at window implantation periodsuperovulated mice.materials and methods: female mice were superovualated then were mated withvasectomized mice; the mice were divided in experimental and control groups.experimental group included five groups which in them pseudopregnant mice weregiven a four consecutive daily injection of 1-progesterone (p), 2-estrogen (e), 3-estrogen + progesterone, 4-antiprogesterone+estrogen and 5-sham group. the uterine ofall groups were collected after 4.5 day of pseudopregnancy and were prepared forhistological and morphometrical studies.results: morphological studies of endometrial tissue showed that the luminalepithelium in group p appeared cuboidal shape. endometrial folding was very high ingroup e+p. the luminal epithelium in groups e, e+p and ru 486 + e were seen indifferent morphology in comparison to control group. morphometrical evaluation alsoshowed height of luminal epithelium in group e (32.7±0.67) and e+p (33.6±1.3) werehigher than those were seen in control (22.5±1.5) and group p (15.3±1.2).conclusion: progesterone caused the lowest endometrial development compare to othergroups. it is concluded that the adding of e to p may improve endometrial condition toimplant at luteal phase.