the il-6 -634c/g polymorphism: a candidate genetic marker for the prediction of idiopathic recurrent pregnancy loss

Background: recurrent pregnancy loss (rpl) is defined as two or more miscarriages before the 20th week of gestation and its etiology is unknown in 50% of the cases. interleukin 6 is an immune mediator, plays a regulatory role in embryo implantation and placental development. objective: the purpose was to assess the association between il-6 -634c/g polymorphism and, susceptibility to idiopathic rpl for the first time in iran. materials and methods: in total 121 women with rpl and 121 healthy women as control group were enrolled in this case-control study. this study was performed from august 2013 to october 2014 in the molecular genetics laboratory of arsanjan university. candidate polymorphism was evaluated by pcr-rflp method on extracted genomic dna. data was analyzed using the statistical spss package. results: our results showed an increased risk of rpl in patients with gg + gc genotype (or=5.1, 95%ci: 1.04-25.3, p=0.04) in comparison to cc genotype. the frequency of mutant allele g in patients and controls was 0.75 and 0.66 respectively. the mutant allele g predisposes women to miscarriage 1.5 times greater than controls (or=1.5, 95%ci: 1.03-2.27, p=0.036). the mean number of live births in rpl women (1.3a±2.3) was significantly lower compared to control women (4.8a±2.3). conclusion: this study indicated that the promoter polymorphism (-634c/g) of the il-6 gene has likely inï ‚uence on individual susceptibility to rpl