Plasma level of vitamin C in women with pre-eclampsia in Ardabil, Iran

Background: pre-eclampsia, a vascular disorder of pregnancy, is a leading cause of maternal morbidityas well as perinatal morbidity and mortality. the cause of pre-eclampsia remains largely unknown.accumulating evidences from clinical and epidemiological studies suggest that diffuse endothelialdysfunction, resulting from oxidative stress, plays an important role in the pathogenesis of pre-eclampsia.independent effect of maternal biological markers, such as elevated triglyceride or low plasma vitamin c(ascorbic acid) concentrations are related to increased pre-eclampsia risk.objectives: the aim of this study was to determine plasma concentrations of vitamin c in women withpre-eclampsia.materials and methods: this cross-sectional, case controlled study comprises 40 pre-eclamptic and 80normo-tensive pregnant women of singleton gestations in thirdtrimester, in allavihospital, ardabil, iran.blood samples (sml) were collected aseptically in heparin tube, and the plasma concentration of vitaminc was determined by spectrophotometric method . spss software package was used for analyzing thedata.results: plasma vitamin c level was found to be significantly lower (p