t 3; 22)(q21;q12) in a pregnant woman with two a ortions and postnatal death of one offspring

Background: carr iers of translocations may have an increased risk of an unbalancedpr geny due to imbalances and delays in meiosis.case: a 24-year-old pregnant iranian female was referred to the genetic department ofyazd linical and research centre for infertility because of her pregnancy history . shehad three previous pregnancies, two of which ended in abortion . the one live borninfant was a girl who had multiple abnormalities and died when she was i i days old.the cytogenetic analysis showed that the woman is a carrier of chromosomaltranslocation 46. xx, t (3; 22) (q21 ; q12), while her husband's karyotype was found tob normal. the karyotype of her mother showed the same translocation . the risk offurther mise rriages was high, and the proband was monitored closely during herpregnancy. after nine months of pregnancy, a normal baby girl weighted 3460 gr wasdelivered by caesarean section. three hours after birth, the baby suffered from jaundiceand respiratory distress. the baby's phenotype was normal. she received routinetr atment successfully and after 15 days she was discharged from the hospital in a goodcondition. the baby's karyotype showed the same translocation as her mother andgrandmoth r.conclusion: to our knowledge, no translocation with such breakpoints t (3; 22) (q2 l ;q 12) has been described previously in the women with rpl.