CA-125 in normal pregnancy and threatened abortion

Background: ca-125 is a glycoprotein and its origin is uncertain during pregnancy. itarises during the first trimester and return to a non-pregnancy range in late pregnancy.objective: the aim of this study was to compare ca-125 level in threatened abortionand normal pregnancy less than 20 weeks of pregnancy.materials and methods: this was a prospective case study carried out on 50 healthypregnant (group 1) and 50 threatened abortion women (group 2). we compared thelevels of ca-125 in these groups and followed them to be informed of the outcome ofpregnan cy.results: fifty percent of women were in 20-24 years old group, primigravida and in thefirst trimester of pregnancy. the mean level of ca-125 in group 1 was 26.2 ± 3.25iu/ml and in group 2 was 37.44 ± 2.72 id/m. the mean level of ca-125 in finallyaborted patients was 58.17±7.25 iu/ml and in normal pregnant women, who continue toterm, was 26.61±l.76 iu/m. the ca-125 level in threatened women,whose pregnancycontinued and did not abort, was 30.89 iu/m. there was statistically significantdifference between mean serum ca-125 levels of two groups (p < 0.05), while therewas no statistically significant difference between these levels in the patients of bothgroups who continued pregnancies (p > 0.1). in group 2, there was a statisticallysignificant difference in the level of ca-125 between those who developed abortion andthose whose pregnancy continued but not aborted (p < 0.05).conclusion: measurement of serum ca-125 may be an inexpensive, easily available,sensitive and specific predictor of outcome in threatened abortion, which results the lossof pregnancy.