Administration of NTG before embryo transfer does not increase pregnancy rate

Background: recent studies of uterine contractility in ivf-embryo transfer led us to consider analtemative, and possibly complementary, explanation for the high implantation rates of blastocysts.it has been demonstrated that myometrial contractile activity influences embryo implantation,possibly through mechanical displacement of embryos.objective: the aim of this study was to examine the effect of nitroglycerine (ntg) treatment forpriming the uterus on the pregnancy outcome oficsi-et programs.materials and methods: this study was a prospective, randomized, double-blinded placebocontrolledclinical trial. one hundred consecutive cycles of icsi-et on infertile couples wererandomly divided into treatment and control groups. the treatment group (50 cycles) received anoral dose of 0.4 mg of ntg, and the control group (50 cycles) received a placebo, 15 minutesbefore fresh et. an informed consent from was obtained form each patients. the main outcomeswere implantation rate (ir) and pregnancy rate (pr).results: the mean age of females in the control group and in the treatment group were 30.1±5.1and 31±5.5 years respectively. data showed that the mean duration of infertility was notsignificantly different between control and treatment groups (6.6±5.8 versus 7.8±5.1 years,respectively). the mean number of oocyte retrieval (metaphase ii) , 2pn, embryo cleaved, embryotransferred and pr weren't different between two groups (p>o.05).overall pr was 36%, it was 38% in treatment group and 34% in control group but there wasn'tstatistically significant difference between two groups. (p>o.05)conclusion: ntg didn't increase pr compared to placebo group. these results suggest that ntgtreatment before et isn't effective in the priming of a uterus.