Comparing the levels of ßHCG, progesterone andestradiol between ectopic pregnancy and normalintrauterine pregnancy

Background: the value of serial measurement of serum 13 subunit of human chorionicgonadotropin (bhcg) and ultrasonography in the early diagnosis of ectopic pregnancyhas well established.objective: the objective of this study was to explore the diagnostic value of raisinglevel of serum bhcg, single measurement of progesterone (p) and estradiol (e2) inearly diagnosis of ectopic pregnancy.materials and methods: serum levels ofbhcg and estradiol were measured by radioimmuno sorbent assay (ria) and progesterone level was measured by enzyme linkedimmuno sorbent assay (elisa) techniques in 43 symptomatic women with ectopicpregnancy and 42 women with normal intrauterine pregnancy in alzahra hospital ,tabriz, iran. these values were compared by t-test. by determining cut-off levels ofthese parameters the efficiency and sensitivity of them in prediction of ectopicpregnancy was estimated.results: the mean serum levels of bhcg, estradiol and progesterone in patients withectopic pregnancies (940 ± 552 mlu/ml, 593 ± 237 pg/ml, 5.83 ± 3.41 ng/ml,respectively) were significantly lower than these levels in normal intrauterinepregnancies (4620 ± 2030 mlu/ml, 1627 ± 435 pg/ml, 24.8 ± 6.08 ng/ml, respectively).the average rate of i3hcg rising was 8.2% for 24 hours in patients with ectopicpregnancy (ep) and 32.8% in normal intrauterine pregnancies (niup).conclusions in this study single measurement of serum progesterone level has thegreatest sensitivity (100%) and specificity (98%) in the diagnosis of ectopic pregnancy.