Association of inherited thrombophilia and antiphospholipid syndrome with severe preeclampsia

Background: severe preeclampsia is a quite well-known entity with high incidence ofboth maternal and fetal morbidity and mortality. although little is known about itsetiology, inherited disorders of hemostasis and antiphospholipid syndrome have beenpostulated as common causes. the present study was conducted to evaluate theassociation of these two entities with preeclampsia in a group of iranian patients .materials and methods: a case-control study was performed on 26 parturients withsevere preeclampsia and 26 healthy pregnant women who were matched according tothe age, parity, gestational age and previous history of abortion. a 10cc blood samplewas obtained and the following factors were measured: factor v leiden, protein s,protein c, antithrombin iii, anticardiolipin antibodies (igm and igg) and the presenceof the lupus anticoagulant antibody.results: we have not found any significant difference in the values of factor v leiden,antithrombin iii, protein c, protein s, and anticardiolipin-igg between preeclamptic(case) and non-preeclamptic (control) parturients. meanwhile, lupus anticoagulantantibody was detected in one case and one control. however, anticardiolipin igm wasshown to be significantly higher in the preeclamptic patients. severe preeclampticparturients were 4.4 times more likely to develop elevated levels of igm (or=4.4, 95%ci=1.9-10, p<0.05).conclusion: our results failed to reveal any significant association betweenpreeclampsia and indices of inherited disorders of hemostasis, except for anticardiolipinigm. thus, routine screening of these indices are not recommended due to highexpenses and shortness of reliability .