The relationship between some endometrial secretion cytokines and in vitro fertilization

Background: endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity. objective: the aim of the present study was to assess the relationship between the success rate of ivf procedures and some endometrial secretion cytokines,including interleukin-1β (il-1β),tumor necrosis factor (tnf-α),interferon gamma-induced protein 10 (ip-10),and monocyte chemoattractant protein (mcp). materials and methods: in a prospective cohort study,50 women selected for ivf met the study inclusion criteria. all the patients underwent endometrial secretion aspiration prior to embryo transfer. the level of il-1β,tnf-α,ip-10 and mcp were analyzed by enzyme-linked immunosorbent assay method using special standard kits. to detect successful implantation and pregnancy patients underwent serum human chorionic gonadotropin measurements and ultrasound evaluation. results: five samples were excluded. nine women (20%) had successful clinical pregnancies,which resulted in live birth. other 36 women (80%) were classified as failed pregnancy. comparison of cytokine levels showed lower concentrations of tnf-α,ip-10,and mcp in the group with successful clinical pregnancy compared to the group with failed pregnancy (p=0.007,0.005 and 0.001,respectively). however,no significant difference was revealed in il-1β levels between two groups (p=0.614). conclusion: the current study suggested that lower concentrations of tnf-α,ip- 10,and mcp in endometrial secretions might be associated with improved endometrial receptivity and ivf outcome. regarding il-1β,no statistically significant differences were seen between the groups with and without successful pregnancy.