Comparison of oral dydrogesterone with vaginal progesteronefor luteal support in IUI cycles: A randomized clinical trial

Background: the aim of this study,we have compared the advantages of oral dydrogestrone with vaginal progesterone (cyclogest) for luteal support in intrauterine insemination (iui) cycles. progesterone supplementation is the first line treatment when luteal phase deficiency (lpd) can reasonably be assumed. objective: this study was conduct to compare the effect of oral dydrogestrone with vaginal cyclogest on luteal phase support in the iui cycles. materials and methods: this prospective,randomized,double blind study was performed in a local infertility center from may 2013 to may 2014. it consisted of 150 infertile women younger than35years old undergoing ovarian stimulation for iui cycles. they underwent ovarian stimulation with oral dydrogesterone (20 mg) as group a and vaginal cyclogest (400 mg) as group b in preparation for the iui cycles. clinical pregnancy and abortion rates,mid luteal progesterone (7daysafter iui) and patient satisfaction were compared between two groups. results: the mean serum progesterone levels was significantly higher in group a in comparison with group b (p=0.001). pregnancy rates in group a was not statistically different in comparison with group b (p =0.58). abortion rate in two groups was not statistically different (p =0.056) although rate of abortion was higher in group b in comparison with a group. satisfaction rates were significantly higher in group a compared to group b (p<0.001). conclusion: we concluded that oral dydrogestrone is effective as vaginal progesterone for luteal-phase support in woman undergoing iui cycles. moreover,the mean serum progesterone levels and satisfaction rates in dydrogestrone group were higher than cyclogest group.