Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial

Background: gonadotrophin-releasing hormone (gnrh) agonist is used for controlling ovarian stimulation in assisted reproductive technology (art) cycles which has some benefits. objective: to compare the efficacy of two different formulations of gnrh agonist: short-acting and long-acting,for art protocols. materials and methods: in a prospective randomized study,one hundred women who underwent art cycles were randomly divided into two groups. in group i,the patients received one single injection of 1.87 mg triptorelin in previous mid-luteal phase. in group ii,decapeptyl 0.1 mg per day started from previous mid-luteal phase. pregnancy outcome in in vitro fertilization (ivf) cycle was compared between two groups. results: there were no statistically significant differences in the number of retrieved oocyte (p=0.545),fertilization (p=0.876),implantation (p=0.716) and pregnancy rate (p=0.727) between the two groups. conclusion: there were not any advantages in ivf outcome between half-dose long-acting and short-acting gnrh agonist groups in art cycle.