Anti-mullerian and androgens hormones in women with polycystic ovary syndrome undergoing IVF/ICSI

Background: despite its frequency, the polycystic ovary syndrome (pcos) is still a difficult diagnosis in endocrinology, gynecology, and reproductive medicine. the rotterdam consensus conference proposed to include the ultrasonographic follicle count as a new diagnostic criterion. unfortunately, its assessment does not offer sufficient reliability worldwide. objective: to explore the possible roles of altered circulating androgens and anti-mullerian hormone among pcos women regarding their body mass index and their outcomes after ivf. materials and methods: in this cross sectional study, 195 women with pco were included, they were divided according to their body mass index (bmi <27 kg/m2) as obese pcos (n=91) and overweight pcos (bmi ≥27 kg/m2) (n=104). serum levels of androgens (dehydroepiandrosterone sulfate [dheas], testosterone and androstenedione [a4]), and anti-mullerian hormone (amh) were assessed and compared with the endocrine profile and cycles outcomes. results: amh, a4, fsh, and tsh concentrations were significantly higher in obese than in overweight women (p˂0.001). contrary, lh: fsh ratio values, e2, prl and dahe-s levels were significantly lower in obese than in overweight women (p˂0.0001). total oocyte retrieved, mature and fertilized oocyte were significantly higher in obese than in overweight women. among pregnant obese pcos women both amh and a4 were significantly increased and dahe-s was significantly decreased compared to pregnant overweight pcos women. conclusion: obese pcos women have a higher chance of getting pregnant over those categorized as overweight pcos. also, androgens and amh levels recommended to be considered in ivf attributes among obese and overweight pcos women.