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Identification of Xq22.1-23 as a region linked with hereditary recurrent spontaneous abortion in a family
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نویسنده
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Shekouhi Sahar ,Baghbani Fatemeh ,Hasanzadeh Nazar-Abadi Mohammad ,Hamzehloie Tayebeh ,Abbaszadegan Mohammad Reza ,Saghafi Nafiseh ,Raoofian Reza ,Reza Javad Zavar ,Ahmadzadeh Shahab ,Tabatabaiefar Mohammad Amin ,Mojarrad Majid
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منبع
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international journal of reproductive biomedicine - 2013 - دوره : 11 - شماره : 8 - صفحه:659 -664
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چکیده
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Background: recurrent spontaneous abortion (rsa) is one of the most common health complications with a strong genetic component. several genetic disorders were identified as etiological factors of hereditary x linked rsa. however, more genetic factors remain to be identified. objective: in this study we performed linkage analysis on a large x linked rsa pedigree to find a novel susceptibility locus for rsa. materials and methods: a linkage scan using 11 microsatellites was performed in 27 members of a large pedigree of hereditary x-linked rsa. two point parametric linkage was performed using superlink v 1.6 program. results: evidence of linkage was observed to markers at xq23, dxs7133 and at xq22.1 dxs101, with lod score of 3.12 and 1.60, respectively. conclusion: identified locus in this study may carry a responsible gene in rsa. narrowing down of this region may leads to identification of this gene.
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کلیدواژه
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X-linked ,Recurrent spontaneous abortion ,Linkage
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آدرس
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mashhad university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, mashhad university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, mashhad university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, mashhad university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, mashhad university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, mashhad university of medical sciences, Qaem Hospital, Department of Gynecology, ایران, mashhad university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, yazd shahid sadoghi university of medical sciences, School of Medicine, Department of Biochemistry, ایران, mashhad university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, ahvaz jundishapur university of medical sciences, School of Medicine, Department of Medical Genetics, ایران, mashhad university of medical sciences, School of Medicine, Department of Medical Genetics, ایران
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Authors
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