Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders

Background: premenstrual dysphoric disorder (pmdd) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women. objective: the aim of this study was to investigate the association of dopamine d3 receptor (drd3) polymorphism, and cannabinoid receptor type 1 (cnr1) polymorphism with pmdd. materials and methods: fifty one participants with documented pmdd according to the dsm iv criteria and 51 healthy controls were included in this cross sectional study. symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. the genotyping of drd3 receptor and cannabinoid type 1 receptors were performed using taqmanfluorogenic assay method. results: distribution of drd3 and cnr1 polymorphism was not different between patients and controls. conclusion: these findings do not support a major role of drd3, and cnr1 polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.