Effect of intramural myomectomy on endometrial HOXA10 and HOXA11 mRNA expression at the time of implantation window

Background: hoxa11 and hoxa10 are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. the expression of these genes is decreased in women with myomas.objective: to determine whether myomectomy would reverse hoxa11 and hoxa10 expression, we evaluated the transcript levels of these genes in the endometria of patients before and after myomectomy.materials and methods: expression of hoxa11 and hoxa10 were examined prospectively during the midluteal phase in endometrium obtained from infertile women (n=12) with myoma before and three months after myomectomy. endometrial hoxa11 and hoxa10 expression were evaluated using quantitative real-time reverse transcriptase-polymerase chain reaction (rt-pcr).results: endometrial hoxa11 and hoxa10 mrnas expression levels (normalized to 18srrna) were increased insignificantly in endometrium of patients after myomectomy (p=0.7 and p=0.15 respectively).conclusion: the results suggest that the alteration in expression pattern of these genes could not account for some aspects of fertility after myomectomy