The accuracy of placental alpha-microglobuline-1 test in diagnosis of premature rupture of the membranes

Background: premature rupture of membranes (prom) is a common obstetric issue during pregnancy which might lead to serious fetal or maternal problems. therefore, an appropriate diagnosis and management of prom are of significant importance in patients.objective: the aim of this study was to determine the accuracy of placental alpha microglobuline-1 (pamg-1) test in prom diagnosis and compare this diagnostic method with other standard tests in diagnosis of prom.materials and methods: in this prospective diagnostic accuracy study, patients with symptoms of membrane rupture in 16-39 weeks of gestation were involved. three tests including fern, nitrazine and pamg-1 were performed at the same time.results: prom was confirmed in 86 patients out of 100. the sensitivity and specificity were respectively 81.3% and 100% for fern test, 93% and 92.8% for nitrazine test, 98.9% and 92.8% for pamg-1 test. pamg-1 test showed higher sensitivity (98.9% with p<0.001) and accuracy (98%) compared with conventional tests. although pamg-1showed a lower positive predictive value (ppv) compared to conventional tests such as fern test (100%), it was shown to be more accurate.conclusion: the accuracy of pamg-1 test was superior to both fern and nitrazine test in prom diagnosis.