Effect of vaginal misoprostol on pregnancy rate after intrauterine insemination: a randomized controlled trial

Background: intrauterine insemination (iui) is one of the most appropriate and cost-effective methods in infertility treatment.objective: we aimed to investigate effect of vaginal misoprostol on pregnancy rate after iui.materials and methods: two hundred and ten infertile women who were referred to infertility clinic of alzahra hospital by an indication of iui during 2012-2013 were randomly assigned to receive 200 ?g vaginal misoprostol (n=105) or vaginal placebo (n=105) after iui. for detecting pregnancy, past 2 weeks, beta human chorionic gonadotropin evaluation was made and if positive, transvaginal sonography was done for evaluation of pregnancy 2-3 weeks later and clinical pregnancy was recorded.results: pregnancy had been noted in 24 patients in misoprotol (22.9%) and 27 patients in placebo (25.7%) groups that this difference was not significant (p=0.748). in misoprostol group, 3 case of nausea and vomiting (2.9%) had been observed.conclusion: according to the results, administering 200 ?g vaginal misoprostol after iui doesn’t have significant effect on the success rate of iui