Expression of Toll-Like Receptors 7-10 in Human Fallopian Tubes

Background: the human female reproductive tract (frt) is constantly deal with the invading pathogens. recognition of these pathogens is attributed to the family of toll like receptors (tlr) as a major part of the innate immune system. we and others have previously revealed that tlrs1-6 express in the female reproductive tract. however, more studies should be done to detect tlrs 7-10 in the female reproductive tract, especially in the fallopian tubes.objective: to examine the expression of tlrs7-10 in human fallopian tube tissue.materials and methods: using immunostaining techniques, distribution of tlr7-10 was studied in surgical sections from the uterine tubes, obtained from patients undergoing tubal ligation and hysterectomy for benign gynecological conditions. rt-pcr was used to show the existence of tlr7-10 genes in fallopian tube tissue.results: tlr7-10 proteins were detected in the fallopian tube epithelium, although the intensity of staining was not equal in cases. tlr7-10 genes were expressed in human fallopian tube tissue.conclusion: this study indicates that tlr7-10 is expressed in fallopian tubes tissues, and may play an important role in microbial recognition, and in host defense against ascending infection.